Figure 5

Possible functions of FasL-interacting SH3 domain proteins. FasL transport, storage, surface expression and reverse signaling depend on the proline-rich N-terminal region. Moreover, FasL is processed by ADAM10 generating an N-terminal fragment (NTF) and subsequently RIPped by SPPL2a generating a free intracellular domain (ICD). This ICD might translocate to the nucleus to regulate gene expression. Although several known SH3 domain proteins have been implicated in FasL storage, transport and surface expression, it is largely unknown how exactly the intracellular translocation but also the retrograde signal transduction or FasL degradation are mediated.