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Table 1 GST-hFasL(1-80)-interacting SH3 domains.

From: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening

Uniprot ID

Entry name

Protein name

Function

Localization

Tissue

SH3 domain

Number of hits

       

total

0.15%

0.5%

P07948

LYN

tyrosine protein kinase Lyn

YK, E

MA

LYM

1/1

43

20

23

O43586

PPIP1*

CD2BP1*

CA

MA

LYM

1/1

42

14

28

Q92882

OSTF1

osteoclast-stimulating factor 1

n.a.

CYT

LYM

1/1

42

20

22

Q8WV41

SNX33

sorting nexin 33

A

CYT, MA

UBI

1/1

15

4

11

P08631

HCK

tyrosine protein kinase Hck

YK, E

MA, CYT

LYM

1/1

14

5

9

P16333

NCK1

Nck1

CA

CYT, MA

LYM

2/3

11

7

4

P07947

YES

tyrosine protein kinase Yes

YK, E

CYT

UBI

1/1

8

2

6

P12931

SRC

tyrosine protein kinase Src

YK, E

CYT

UBI

1/1

8

5

3

Q9Y5X1

SNX9

sorting nexin 9

A

CYT, MA

LYM

1/1

6

6

0

Q7Z6B7

SRGP1

SLIT-ROBO Rho GAP 1

R

MA

UBI

1/1

6

3

3

A1X283

SPD2B

SH3 and PX domain containing protein 2B

n.a.

CYT

UBI

3/4

6

3

3

A1X283

SPD2B

SH3 and PX domain containing protein 2B

n.a.

CYT

UBI

4/4

5

3

2

Q06187

BTK

tyrosine protein kinase Btk

YK, E

CYT, MA

LYM

1/1

5

5

0

Q8TE67

EPS8L3

EGFR kinase substrate 8-like protein 3

A

CYT

UBI

1/1

4

3

1

Q9BRR9

RHG09

ARHGAP9

R

CYT, MA

LYM

1/1

4

1

3

Q9UKN7

MYO15

Myosin XV

CA

CYT

UBI

1/1

3

3

0

O43639

NCK2

Nck2

CA

CYT, MA

LYM

2/3

3

2

1

O15117

FYB

Fyn-binding protein

A

CYT, NUC

LYM

1/1

2

2

0

P42680

TEC

tyrosine protein kinase Tec

YK, E

CYT

UBI

1/1

2

2

0

P02549

SPTA1

spectrin alpha chain

CA

CYT

ERY

1/1

2

2

0

Q9NSI8

SAMN1

SAM domain-containing protein SAMSN-1

n.a.

n.a.

LYM

1/1

2

2

0

Q8TEC5

SH3R2

putative E3 ubiquitin protein ligase SH3RF2

E, R

n.a.

UBI

3/3

2

2

0

Q15700

DLG2

disks large homology 2

CA, R

MA

NL

1/1

2

1

1

O60504

VINEX

vinexin

CA

MA, CYT

NL

2/2

2

1

1

O75563

SKAP-2

Src kinase-associated phosphoprotein 2

CA

MA, CYT

LYM

1/1

2

1

1

P46108

CRK

proto-oncogene c-Crk/p38

A

MA, CYT

NL

2/1

1

0

1

Q9NZQ3

SPN90

SH3 adapter protein SPIN90

A, CA

NUC

UBI

1/1

1

0

1

Q5TCZ1

SPD2A

SH3 and PX domain containing protein 2A

A

CYT, MA

UBI

5/5

1

0

1

Q9UHR4

BI2L1

brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1

CA

CYT

UBI

3/3

1

0

1

Q99963

SH3G2

endophilin-A3

A

CYT, MA

UBI

1/1

1

0

1

O95049

ZO3

tight junction protein ZO-3

A

CYT, MA

UBI

1/1

1

0

1

P54284

CACB3

voltage-dependent L-type calcium channel subunit beta-3

E

MA

NL

1/1

1

0

1

Q96JB8

MPP4

MAGUK p55 subfamily member 4 (isoform 2)

A

CYT

UBI

1/1

1

0

1

-

-

N-Src

-

-

-

1/1

1

0

1

P27986

P85A

PI3K regulatory subunit alpha

R, A

MA

LYM

1/1

1

0

1

Q6XZF7

DNMNP

dynamin-binding protein

CA

MA, GOL

UBI

4/6

1

0

1

Q8N1I0

DOCK4

dedicator of cytokinesis protein 4

R, A

MA

NL

1/1

1

1

0

O60229

KALRN

kalirin

R, CA

MA

NL

1/2

1

1

0

Q6ZN28

7A5

SH3 domain-containing protein 7A5

TF

CYT, NUC

UBI

1/1

1

1

0

O43295

SRGP3

SLIT-ROBO Rho GAP 3

R

MA

NL

2/3

1

1

0

P06241

FYN

tyrosine protein kinase Fyn

YK, E

MA

LYM

1/1

1

1

0

Q16674

MIA

melanoma-derived growth regulatory protein

n.a.

SEC

NL

1/1

1

1

0

O75044

FNBP2

SLIT-ROBO Rho GAP 2

R

MA

NL

1/1

1

1

0

Q9NZM3

ITSN2

intersectin 2

A, CA

CYT

LYM

2/5

1

1

0

P14598

NCF1

p47phox

A

CYT

NL

1/2

1

1

0

Q08881

ITK

tyrosine protein kinase Itk

YK, E

MA

LYM

1/1

1

1

0

O00305

CACB4

voltage-dependent L-type calcium channel subunit beta-4

E

MA

NL

1/1

1

1

0

A6NJZ7

RIM3C

RIMS-binding protein 3C

n.a.

MA, CYT

n.a.

2/3

1

1

0

  1. Individual interactors identified by phage display screening are listed according to their Uniprot ID, the respective entry name and the full protein name. In addition, putative protein function and subcellular localization of individual proteins are given according to the respective Uniprot entries. Primary tissue-specific expression is indicated according to the BioGPS database (Genomics Institute, Novartis Research Foundation). The number of hits is given in total and separately for the two applied detergent concentrations. SH3 domains binding to the GST control were excluded from the list.
  2. *Point mutation detected in the provided SH3 domain of CD2BP1
  3. Abbreviations:
  4. Function: YK, tyrosine protein kinase; E, enzymatic acitivity; CA, cytoskeleton-associated (adapter) protein; n.a., not annotated; A, adapter protein; R, regulatory protein; TF, transcription factor
  5. Localization: MA, membrane-associated; CYT, cytosolic; GOL, Golgi; NUC, nuclear; SEC, secreted; n.a., not annotated
  6. Tissue distribution: LYM, lymphoid; UBI, ubiquitous; ERY, erythroid; NL, non-lymphoid; n.a., not annotated
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BMC Immunology

ISSN: 1471-2172

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