Figure 5
From: Selenoproteins regulate macrophage invasiveness and extracellular matrix-related gene expression
Altered gene expression in ΔTrspMmacrophages. (A) Genes upregulated (red spots) and downregulated (green spots) in ΔTrspMBMDMs were shown in the scatter plots. Numbers on the ordinate and abscissa represent logarithmic values of the intensity of signal of individual microarray spots. The cut-off lines indicate the margins of gene expression ratio: 3-fold or higher (upregulated genes; red) and 3-fold or lower (downregulated genes; green). (B) The expression levels of genes identified in DNA microarray analysis were validated by real-time qPCR. Shown is the relative expression of genes in BMDMs left untreated and treated with LPS (100 ng/ml; 4 h). Data are representative of two experiments. All genes presented exhibited statistically significant differences in their expression levels in WT and ΔTrspMBMDMs. (C) Genes and protein products whose expression is regulated by selenoproteins.