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Figure 1 | BMC Immunology

Figure 1

From: Induction of granzyme B expression in T-cell receptor/CD28-stimulated human regulatory T cells is suppressed by inhibitors of the PI3K-mTOR pathway

Figure 1

CD4, CD25, granzyme B and FOXP3 expression patterns in freshly isolated Treg-depleted peripheral blood CD4+, CD25- conventional T cells (panel A) and enriched CD4+, CD25+ natural regulatory T cells (panel B). Utilizing a CD4/CD25 magnetic bead-based technique, the enriched samples of nTregs were routinely comprised of 60-70% Tregs based on FOXP3 expression. This data is representative of that seen in multiple subsequent experiments utilizing enriched Tregs. Similar results were obtained in 4 normal donors.

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