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Figure 2 | BMC Immunology

Figure 2

From: Gallin; an antimicrobial peptide member of a new avian defensin family, the ovodefensins, has been subject to recent gene duplication

Figure 2

The ovodefensin family. A) CLUSTALW 2.0.11 multiple sequence alignment of ovodefensins. Only the mature peptides are used. Conserved cysteines are shown with a light shaded background and cationic residues with a black background and white type. Complete conservation is indicated with '*', similarity with ':', and weakly similar with '.'. The relative charge is indicated at the end of each sequence. Where the Latin name has been used as the basis for the peptide name the common name for the species can be found in part C adjacent to the peptide names. B) Aligned sequence of two peptides closely related to the ovodefensins found in duck and zebra finch. Legend as A. C) A phylogram indicating the evolutionary history of the ovodefensins was inferred using the Neighbor-Joining method [41] from an alignment of the mature peptides shown in A and B. The tree is the consensus of 1000 replicates with the percentage of replicate trees in which the branches clustered together in the bootstrap test shown next to the branches. Branches corresponding to partitions reproduced in less than 50% of bootstrap replicates are collapsed. All positions containing alignment gaps and missing data were eliminated only in pairwise sequence comparisons. The common name for the species where the peptides have been isolated can be found to the right of the peptide names. We can see that the 3 molecules identified in the chicken are more similar to each other than the molecules from the other species.

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