Table 1 Antiviral and antibacterial activity of apolipoprotein-derived peptides.
Category | Apolipoprotein | Peptide | Amino Acid Sequence | IC50 Concentration (μM) | ||
|---|---|---|---|---|---|---|
HSV1 | P. aeruginosa | S. aureus | ||||
Amphipathic α-helical domain derived | AI | apoA1-H4 | PYLDDFQKK WQEEMELYR QK VE | - | - | - |
apoA1-H6 | PLGEEMR DR AR AHVDALR THLA | - | - | - | ||
apoA1-H7 | PYSDELR QRLAAR LEALK ENGG | - | - | - | ||
apoA1-H8 | ARLAEYHAK ATEHLSTLSEK AK | - | - | - | ||
apoA1-18A | DWLK AFYDK VAEK LK EAF | 36 | - | - | ||
apoA1-consensus | PVLDEFR EK LNEELEALK QKMK | - | - | - | ||
AII | apoAII 18-35 | VTDYGK DLMEK VK SPELQ | - | - | - | |
apoAII 18-30+ | VTDYGK DLMEK VK EWLNS | - | - | - | ||
J | apoJ151-170 | HMLDVMQDHFSR ASSIIDEL | >40 | - | - | |
apoJ219-236 | NFHAMFQPFLEMIHEAQQ | - | - | - | ||
apoJ311-329 | LQVAER LTRK YNELLK SYQ | - | - | - | ||
apoJ409-424 | K FMETVAEK ALQEYRK | - | - | - | ||
HSPG/heparin binding domain derived | B | apoB1000-1016 | R ALVDTLK FVTQAEGAK | - | - | - |
apoB(3359-3367)dp | R LTRKR GLKR LTRKR GLK | >40 | - | - | ||
E | apoE128-149 | QSTEELR VR LASHLRK LRKR LL | 36.5 | 54 | - | |
apoE(141-149)dp | LRK LRKR LLLRK LRKR LL | 16.5 | 2.5 | 9 | ||
apoE141-162 | LRK LRKR LLR DADDLQKR LA | >40 | - | - | ||
apoE(150-158)dp | R DADDLQKRR DADDLQKR | >40 | - | - | ||
apoE(211-219)dp | GER LR AR MEGER LR AR ME | >40 | - | - | ||
apoE(213-221)dp | R LR AR MEEMR LR AR MEEM | >40 | - | - | ||
H | apoH(281-288)dp | CK NK EKK CCK NK EKK C | - | - | - | |