Figure 1

Paclitaxel inhibits mitochondrial activity in tumour cell lines and DC as assessed by MTS/PMS assay. Tumour cell lines MJT-3 (black squares), MCF7-pR (grey squares) and DC (white squares) were incubated with paclitaxel for 2 h before being washed and returned to culture for 48 h. Sensitivity was determined by the addition of MTS/PMS for triplicate samples ± SD. Each experiment was repeated 3 times and DC from 3 individual donors evaluated. Representative histograms from one experiment are shown. At lower doses (up to 0.5 μmol) of paclitaxel, the DC are more resistant than tumour cells (p value = 0.003). DC were more resistant overall than MCF7-pR.