Figure 5
From: Differential effects of Paclitaxel on dendritic cell function
Effects of Paclitaxel versus LPS on the ability of DC to produce inflammatory cytokines. DC treated with LPS or paclitaxel for 2 hours were extensively washed and returned to culture for 24 h. Supernatants were collected and analysed by CBA for the presence of A; IL-12; B, TNFα; C, IL-10; D, IL-1β; EIL - 8. Overall, paclitaxel appeared to reduce cytokine secretion by DC compared to LPS; significant increases of IL-1β secretion were seen at lower doses of paclitaxel.