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Figure 6 | BMC Immunology

Figure 6

From: Differential effects of Paclitaxel on dendritic cell function

Figure 6

Paclitaxel induced alterations to DC morphology and cytoskeletal organisation similar to LPS. DC were adhered to fibronectin-coated coverslips prior to treatment with LPS +/- Paclitaxel for 2 h. The cells were extensively washed before being stained for microtubule arrangements and analysis by microscopy. Representative figures from 4 experimental repeats are shown. A, non-treated DC; B; 1 μM paclitaxel; C, 100 μM paclitaxel; D, 1 μg/ml LPS. In keeping with its known action, exposure to paclitaxel resulted in microtubule stabilisation but marked changes in DC morphology reduction in cell size, rounding and loss of dendrites.

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