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Table 1 Expression of DC surface markers in response to paclitaxel.

From: Differential effects of Paclitaxel on dendritic cell function

   

Taxol(μM)

Marker

No Drug

LPS

1

10

100

HLA Class II

625

1265

690

888

1109

HLA Class I

93

274

95

85

87

CD40

4

7

6

6

7

CD80

40

95

57

61

51

CD83

5

22

4

5

4

CD86

18

71

27

26

33

  1. DC were incubated with paclitaxel at various concentrations or LPS (1 μg/ml) for 2 h before being washed and returned to culture for a further 24 h. Surface expression of various molecules was assessed by flow cytometry as outlined in the materials and methods. The panel reports the delta MFI (the difference between isotype-matched mAb and specific mAb) mean fluorescence intensity (MFI). Data representative of 5 independent experiments.