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Table 1 Expression of DC surface markers in response to paclitaxel.

From: Differential effects of Paclitaxel on dendritic cell function

    Taxol(μM)
Marker No Drug LPS 1 10 100
HLA Class II 625 1265 690 888 1109
HLA Class I 93 274 95 85 87
CD40 4 7 6 6 7
CD80 40 95 57 61 51
CD83 5 22 4 5 4
CD86 18 71 27 26 33
  1. DC were incubated with paclitaxel at various concentrations or LPS (1 μg/ml) for 2 h before being washed and returned to culture for a further 24 h. Surface expression of various molecules was assessed by flow cytometry as outlined in the materials and methods. The panel reports the delta MFI (the difference between isotype-matched mAb and specific mAb) mean fluorescence intensity (MFI). Data representative of 5 independent experiments.