Table 4 Epitope binding predictions for DRB1 alleles that are common in TB high-burden countries
DRB1 Allele 1 | Median total (conserved) epitopes | N 2 | Association with tuberculosis (reference) | Tuberculosis-endemic populations where allele is highly prevalent 4 |
|---|---|---|---|---|
0101 | 122 (76) | 9 | NK3 | Russian Chuvash, Aleuts and Tuva, Indian Islamic populations |
0102 | 46 (30) | 3 | NK | Ethiopia (Amhara) |
0301 | 11 (4) | 6 | Protective [29] | Brazil, northern China, Ethiopia (Oromo), northern and eastern India, northwestern Russia, Thailand (Bangkok), South Africa (Venda) |
0302 | 0 (0) | 1 | NK | South Africa (Venda) |
0401 | 29 (15) | 8 | NK | Chinese Inner Mongolian Evenki, Russian Chukchi, Eskimo, Koryak, Buryat, and Negidal populations |
0403 | 11 (4) | 1 | NK | Russian Buryat and Nganasan populations |
0404 | 16 (8) | 6 | NK | Brazil Kaingang indigenous population |
0405 | 20 (11) | 6 | NK | Philippines |
0411 | 7 (3) | 1 | NK | Brazil indigenous populations |
0701 | 16 (9) | 8 | Protective [29] | Brazil, Northern and Eastern China, Democratic Republic of the Congo, Ethiopia, Indonesia (Java), Russian Bearian Island Aleuts, Russia Chuvash, Russia (Siberia), Thailand (Bangkok), Vietnam (Hanoi) |
0801 | 9 (7) | 2 | Susceptible [29] | Russia (Kets) |
0802 | 7 (3) | 4 | Susceptible [29] | Brazil indigenous populations, Russian Eskimos |
0803 | 2 (1) | 1 | Susceptible [52] | China (Yunnan Province) |
0804 | 7 (5) | 2 | NK | Brazil East Amazon indigenous populations |
0807 | 2 (2) | 1 | NK | Brazil Guarani Kaiowa and Ticuna indigenous populations |
0901 | 23 (10) | 5 | NK | Brazil Southeast Caucasian population, China, Russia (Siberia), Thailand, Vietnam (Hanoi) |
1001 | 138 (77) | 1 | NK | Northern and eastern India, Russian Buryat population |
1101 | 13 (5) | 7 | Northeast Brazil, Northern and central China, Democratic Republic of the Congo, northern India, Indonesia (Molucca and Nusa Tenggara), Russian Evenks, Nganasan, and Tuva populations, Zimbabwe (Harare) | |
1201 | 13 (7) | 2 | NK | China (Southern and Harbin), northeast India, Russia (Siberia) |
1202 | 8 (2) | 1 | NK | Southern and central China, Hong Kong and Singapore, Indonesia, Philippines, Thailand, Vietnam (Hanoi) |
1301 | 8 (5) | 4 | Protective [29] | Brazil, China (Xinjiang), Democratic Republic of the Congo, India (Andhra Pradesh), Russia (Kets, Khanty-Mansi), South Africa (Venda), Zimbabwe (Harare) |
1302 | 14 (8) | 6 | Brazil Southeast Mulattos, Democratic Republic of the Congo, Ethiopia | |
1303 | 9 (5) | 1 | NK | Democratic Republic of the Congo, Northeast India |
1401 | 5 (3) | 1 | Susceptible [29] | Southern China, Northern India, Philippines, Russian Nivkhi and Evenki, Udege, and Ulchi, Vietnamese Muong |
1402 | 19 (8) | 1 | NK | Brazil Xavantes, Guarani, and Terena; Russian Chukchi, Eskimos, Koryaks, Nivkhi, and Udege |
1403 | 2 (0) | 1 | NK | Chinese Drung, Russian Evenki and Kets |
1404 | 3 (2) | 1 | NK | China Naxi and Lisu, India (Delhi) |
1405 | 10 (3) | 1 | NK | Chinese Wa Population |
1413 | 38 (19) | 1 | NK | Brazil Guarani M bya population |
1501 | 15 (9) | 8 | China, Hong Kong and Singapore, India, Indonesia, Russia (Siberia), Northeast Thailand | |
1502 | 12 (5) | 2 | Susceptible [29] | Chinese Jino population, India, Indonesia, Philippines, Thailand, Vietnam |
1503 | 15 (8) | 1 | NK | Zimbabwe (Harare) |
1504 | 6 (2) | 1 | NK | Chinese Nu and Va populations |
1602 | 17 (6) | 1 | NK | Brazil Xavantes, Guarani, Kaingang, Terena, and Ticuna populations, Chinese Maonan and Miao populations, Northern Thailand, Vietnamse Muong |