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Table 3 Survival analysis using a Cox regression model.

From: Tumor infiltrating lymphocytes: an intriguing player in the survival of colorectal cancer patients

 

Overall survival

Disease free survival

 

Cox Regression

Cox Regression

 

HR

95%CI

p-value

HR

95%CI

p-value

MSI

0.38

0.12

1.18

0.09

0.33

0.09

1.27

0.11

Age

1.04

1.00

1.07

0.04

0.97

0.92

1.01

0.14

Gender

1.41

0.79

2.53

0.25

1.45

0.68

3.13

0.34

Localization

0.71

0.38

1.31

0.27

1.16

0.47

2.84

0.75

Grade of differentiation

0.70

0.43

1.13

0.15

0.53

0.34

1.09

0.05

stage

2.37

1.58

3.56

< 0.001

2.70

1.51

4.83

< 0.001

adjuvant treatment

0.70

0.29

1.68

0.43

1.03

0.36

2.97

0.96

CD8IM

1.24

0.56

2.75

0.59

0.82

0.29

2.36

0.71

CD8ST

0.89

0.38

2.10

0.79

1.95

0.66

5.76

0.22

CD8CC

2.06

0.67

6.39

0.21

0.68

0.16

2.88

0.60

CD3IM

0.97

0.40

2.32

0.94

0.86

0.27

2.75

0.80

CD3ST

1.05

0.51

2.19

0.89

0.66

0.24

1.85

0.43

CD3CC

0.54

0.18

1.59

0.26

1.61

0.44

5.95

0.48

GRBIM

0.59

0.24

1.44

0.24

1.14

0.37

3.52

0.81

GRBST

0.86

0.37

2.00

0.72

0.53

0.17

1.65

0.27

GRBCC

1.18

0.45

3.13

0.74

2.18

0.62

7.61

0.22

  1. Survival analysis of colorectal cancer patients using a multiple Cox regression model. (HR: hazard ratio, CI: confidence interval, IM: invasive margin, ST: stroma, CC: cancer cell nests, GRB: granzyme B, MSI: microsatellite instability).