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Figure 1 | BMC Immunology

Figure 1

From: GPR30, but not estrogen receptor-α, is crucial in the treatment of experimental autoimmune encephalomyelitis by oral ethinyl estradiol

Figure 1

Treatment with ethinyl estradiol (EE; 1 mg/day) reduced disease severity in ovariectomized wild-type (WT) mice (A) and estrogen receptor-α knockout (ERKO) mice (B), while mice lacking the G-protein coupled estrogen receptor (GPR30KO; C) showed no improvement in disease severity. WT: N = 12 per group. ERKO: Ctrl N = 9, EE N = 10. GPR30KO: Ctrl N = 13, EE N = 12. * indicates p < .04

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