Figure 26
A cladistic model for the evolution of IRF family members. Two rounds of duplication of the whole genome are inferred to have occurred by the base of vertebrates, and tandem duplication, perhaps even an extra round of tetraploidization in zebrafish lineage. Subsequent independent gene duplication and/or loss events were marked on the tree. Hs: human Homo sapiens; Mm: mouse Mus musculus; Cf: dog Canis familiaris; Gg: chicken Gallus gallus; Ac: anole lizard Anolis carolinensis; Xt: frog Xenopus tropicalis; Tr: fugu Takifugu rubripes Ga: stickleback Gasterosteus aculeatus; Dr: zebrafish Dario rerio; ND: non-vertebrate deterostomes.