TY - JOUR AU - Weinstein, Raymond S. AU - Weinstein, Michael M. AU - Alibek, Kenneth AU - Bukrinsky, Michael I. AU - Brichacek, Beda PY - 2010 DA - 2010/05/18 TI - Significantly reduced CCR5-tropic HIV-1 replication in vitro in cells from subjects previously immunized with Vaccinia Virus JO - BMC Immunology SP - 23 VL - 11 IS - 1 AB - At present, the relatively sudden appearance and explosive spread of HIV throughout Africa and around the world beginning in the 1950s has never been adequately explained. Theorizing that this phenomenon may be somehow related to the eradication of smallpox followed by the cessation of vaccinia immunization, we undertook a comparison of HIV-1 susceptibility in the peripheral blood mononuclear cells from subjects immunized with the vaccinia virus to those from vaccinia naive donors. SN - 1471-2172 UR - https://doi.org/10.1186/1471-2172-11-23 DO - 10.1186/1471-2172-11-23 ID - Weinstein2010 ER -