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Figure 3 | BMC Immunology

Figure 3

From: Beta-escin has potent anti-allergic efficacy and reduces allergic airway inflammation

Figure 3

Beta-escin reduces total cells and eosinophil recruitment in an OVA-induced model of allergic airway inflammation. BALB/c mice were sensitized with OVA on days 0, 14 and 21. The aerosol challenges with OVA or PBS were performed twice a day on days 28 and 29. 40 h after the last aerosol challenge, the mice were sacrificed for the analyses of the airway inflammation of the lungs. Groups were treated as follows: control group = PBS-challenged, treated with PBS; PBS group = OVA-challenged, treated with PBS; dex group = OVA-challenged, treated with dexamethasone (1 mg/kg, once a day) and escin group = OVA-challenged, treated with beta-escin (3 mg/kg, twice a day). Groups were compared with respect to the total cell counts (A) and the number of eosinophils (B) in the BALFs. Each bar represents the mean of 13 - 21 mice from 4 independent, but identical experiments ± SEM out of a series of similar experiments. Significant differences of the dex and escin groups to the PBS group are indicated with: ** p < 0.01 and *** p < 0.001.

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