IL-4 production is elevated in 7 to 10 weeks Sj infected DBA/1 mice. Splenocytes from DBA/1 mice infected with Sj either for 2 weeks or 7 to 10 weeks or not infected (CTRL) were stimulated by anti-CD3 and anti-CD28 antibodies for 72 hours in vitro. The supernatants were analyzed for IL-4 (A) and IFN-g (B). Shown are the combined results from two separate experiments. Significance was tested by one-way ANOVA with Bonferroni multiple comparison test with *** and ** as p < 0.001 and p < 0.01.