TY - JOUR AU - Zhang, Mingjie AU - Daniel, Sylvester AU - Huang, Yong AU - Chancey, Caren AU - Huang, Qingsheng AU - Lei, Ying F. AU - Grinev, Andriyan AU - Mostowski, Howard AU - Rios, Maria AU - Dayton, Andrew PY - 2010 DA - 2010/01/20 TI - Anti-West Nile virus activity of in vitro expanded human primary natural killer cells JO - BMC Immunology SP - 3 VL - 11 IS - 1 AB - Natural Killer (NK) cells are a crucial component of the host innate immune system with anti-viral and anti-cancer properties. However, the role of NK cells in West Nile virus (WNV) infection is controversial, with reported effects ranging from active suppression of virus to no effect at all. It was previously shown that K562-mb15-41BBL (K562D2) cells, which express IL-15 and 4-1BBL on the K562 cell surface, were able to expand and activate human primary NK cells of normal peripheral blood mononuclear cells (PBMC). The expanded NK cells were tested for their ability to inhibit WNV infection in vitro. SN - 1471-2172 UR - https://doi.org/10.1186/1471-2172-11-3 DO - 10.1186/1471-2172-11-3 ID - Zhang2010 ER -