Course of disease and parasite burden in L. panamensis infected hamsters. 6-8 week old female hamsters (n = 6) with 3 × 106 luciferase (luc)-transfected L. panamensis promastigotes in the dermis of the snout. Lesion size was measured weekly and is shown as the lesion area (mm2) in panel A. The intralesional parasite burden was determined by in vivo imaging and is shown as the total intralesional amastigotes in panel B. Images of the luc-L. panamensis burden in two representative hamsters are shown in panel C.