Table 1 Concentration (pg/ml) of 20 biomarkers measured prior to and 1 month after BCG vaccination of UK adolescents (values given are group median and interquartile range calculated after individual measurements were background corrected (PPD-stimulated - unstimulated values); n = 12)

IL-1α

50.6 (15.2-64.6)

8.0

86.9 (73.4-116.6)*

11.5

IL-1β

1.6 (1.6-1.6)

1.6

1.6 (1.6-1.6)

1.6

IL-2

1.6 (1.6-2.8)

1.6

8.0 (4.6-12.1)*

1.6

IL-4

1.6 (1.6-1.8)

1.6

6.8 (1.6-40.1)

1.6

IL-5

1.6 (1.6-1.6)

1.6

1.6 (1.6-3.9)

1.6

IL-6

310.0 (140.5-537.7)

1.6

751.6 (521.8-1018.0)*

3.8

IL-7

1.6 (1.6-1.6)

1.6

1.6 (1.6-1.6)

1.6

IL-8

728.1 (656.4-5678.0)

58.5

7534.0 (4082.0-23400.0)

66.2

IL-10

20.8 (4.7-61.4)

1.6

153.8 (93.8-279.3)*

1.6

IL-12p70

1.6 (1.6-1.6)

1.6

1.6 (1.6-1.6)

1.6

IL-13

1.6 (1.6-1.6)

2.8

10.3 (2.8-17.6)

2.4

IL-15

1.6 (1.6-1.6)

1.6

1.6 (1.6-1.6)

1.6

IL-17

2.6 (1.6-9.0)

1.6

72.3 (14.1-111.7)*

1.6

IFNγ

5.3 (1.6-79.6)

1.6

1273.0 (373.8-2815.0)*

1.6

TNF-α

23.0 (11.7-38.3)

2.6

105.2 (45.8-176.3)*

1.6

GM-CSF

21.0 (9.4-29.5)

4.3

125.7 (56.8-216.6)*

5.9

G-CSF

1.6 (1.6-2.7)

1.6

3.6 (1.6-19.6)

1.6

MIP-1α

8.3 (1.6-16.0)

1.6

54.6 (18.5-138.8)*

1.6

IP-10

548.6 (169.5-2881.0)

33.1

8866.0 (6901.0-15000.0)*

52.4

EOTAXIN

1.6 (1.6-6.5)

34.1

1.6 (1.6-4.1)

8.8