Figure 4

Circulating FoxP3⁺ T _REG cells and CD4⁺ CD25^HIGH T cells in AML patients and healthy controls. The levels of CD4⁺ FoxP3⁺ T_REG cells and CD3⁺ CD4⁺ CD25^HIGH T cells were analyzed for patients with untreated AML (AML, n = 16), patients with chemotherapy-induced cytopenia (Cytopenia, n = 16; the first cohort of patients) and during hematopoietic reconstitution after chemotherapy (Reconstitution, n = 6); these results were compared with healthy controls (n = 30). The levels are presented as the percentage of each cell type among CD4⁺ T cells. No age-dependent differences were observed in the control group. All results are presented as median (horizontal line), 25^th to 75^th percentiles (boxes) and variation range (whiskers). Statistically significant differences are presented at the top of the figures (Mann-Whitney test).