Figure 4

Generation of a biological network of genes of the most significant Canonical Pathways for the Il10-/- (EF·CIF vs. C) comparison. The network was generated by IPA using all molecules from significantly affected Canonical Pathways (Oxidative Phosphorylation; Antigen Presentation Pathway; IL-10 Signaling; Interferon Signaling; LPS/IL-1 mediated inhibition of RXR function; Circadian Rhythm Signaling). Connections were applied based on known interactions between these genes within the Ingenuity Pathways Knowledge Base. Central genes and their direct interactions were identified and were supported by published information. *Genes that are detected 2 or more times on the array. Genes or gene products are represented as nodes, and the biological relationship between two nodes is represented as a line (i.e. an edge). All edges are supported by at least 1 reference from the literature. Red and green coloured nodes indicate genes with up- and down-regulated expression, respectively. The intensity of the colours specifies the degree of up- or down-regulation. Greater intensity represents a higher level of differential expression. Nodes and edges are displayed with various shapes and labels that present the functional class of genes and the nature of the relationships between the nodes, as shown in the legend to Figure 3.