|  | Mouse strain | P(Il10-/-vs. C57) |
---|
Assay | Treatment Group |
Il10
-/-
| C57 | Â |
---|
SAA | SPF | 60.1 ± 30.4 | 7.1 ± 6.6 | < 0.05 |
 | C | 43.9 ± 24.4 | 6.5 ± 4.7 | < 0.05 |
 | EF | 140.5 ± 136.3 | 6.4 ± 7.5 | < 0.05 |
 | CIF | 43.5 ± 11.4 | 6.5 ± 14.2 | < 0.05 |
 | EF·CIF | 137.4 ± 161.1 | 50.6 ± 90.9 | < 0.05 |
IL-1α | SPF | 40.4 ± 39.6 | 25.0 ± 34.6 | NS |
 | C | 11.3 ± 25.2 | 38.3 ± 36.3 | NS |
 | EF | a 80.3 ± 67.5 | 9.5 ± 21.2 | 0.03 |
 | CIF | 0.0 ± 0.0 | 55.2 ± 59.4 | NS |
 | EF·CIF | 44.9 ± 49.1 | 55.4 ± 59.6 | NS |
IL-4 | SPF | 1.0 ± 1.0 | 1.8 ± 1.1 | NS |
 | C | 1.0 ± 0.9 | 1.0 ± 0.5 | NS |
 | EF | b 0.3 ± 0.6 | b 0.5 ± 0.4 | NS |
 | CIF | 1.0 ± 1.9 | 1.0 ± 0.5 | NS |
 | EF·CIF | c 0.4 ± 0.5 | c 0.8 ± 1.6 | NS |
IL-5 | SPF | 33.4 ± 0.6 | 59.6 ± 57.0 | NS |
 | C | 19.9 ± 18.2 | 33.2 ± 1.7 | NS |
 | EF | 31.1 ± 19.3 | 35.9 ± 3.3 | NS |
 | CIF | 55.4 ± 68.6 | 26.7 ± 15.0 | NS |
 | EF·CIF | 22.1 ± 20.4 | d 13.2 ± 18.1 | NS |
IL-6 | SPF | 2.4 ± 3.3 | 0.0 ± 0 | NS |
 | C | 5.2 ± 11.5 | 6.1 ± 6.8 | NS |
 | EF | e 59.7 ± 30.0 | 5.4 ± 8.4 | 0.03 |
 | CIF | 8.0 ± 16.0 | 5.9 ± 8.9 | NS |
 | EF·CIF | 25.3 ± 24.5 | 0.03 ± 0.08 | 0.03 |
- Data represent mean ± SD of plasma levels of SAA and IL-6 for 5 mice (except for Il10-/-mice in the CIF group, n = 4) fed AIN-76A diet, and in treatment groups described in the legend to Table 3. P-values are for across-group comparisons between Il10-/-and C57 mice under the same treatment conditions (NS denotes not significantly different between strains). Superscript letters denote mice with values significantly different (P < 0.05) from mice of the same strain in different treatment groups as follows: (a) EF-inoculated Il10-/-mice showed significantly higher IL-1α levels than Il10-/-mice in the C and CIF groups; (b) IL-4 in the EF groups was significantly lower than in the SPF and C groups in both mouse strains; (c) IL-4 in the EF·CIF group was significantly lower than that in the SPF group in both mouse strains; (d) across the C57 mice, those receiving the EF·CIF inoculation had significantly lower IL-5 levels than either EF or SPF; (e) Il10-/-mice in the EF inoculation group had significantly higher IL-6 than all other Il10-/-treatment groups except for EF·CIF.