Figure 2
From: Effects of F/G-actin ratio and actin turn-over rate on NADPH oxidase activity in microglia
Over-expression of p47phox alleviates the effects of latrunculin and jasplakinolide. Superoxide production of Ra2 cells over-expressing p47phox wild type (A,B) or the p47phox (S303D/S304D/S328D) mutant (C,D) and treated with increasing doses of latrunculin (A,C) or jasplakinolide (B,D) before stimulation with PMA. The ordinate in arbitrary units shows luminol E-CL signal normalized to cells receiving no toxin (no add.), and results are presented as mean of at least three independent experiments. Arrows indicate time point of agonist injection.