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Figure 4 | BMC Immunology

Figure 4

From: Tumor vaccine composed of C-class CpG oligodeoxynucleotides and irradiated tumor cells induces long-term antitumor immunity

Figure 4

Survival curves of mice re-challenged i.p. with 5 × 105viable B16F1 tumor cells. Pre-vaccinated mice surviving the first tumor challenge were without any additional treatment re-challenged 100 days after the first tumor challenge. Control: mock treated; 1 × 90: vaccine + two additional injections of CpG ODNs applied once 90 days before tumor inoculation; 2 × 90: vaccine + two additional injections of CpG ODNs applied twice 90 and 75 days before tumor inoculation; 3 × 90: vaccine + two additional injections of CpG ODNs applied three times 90, 75 and 60 days before tumor inoculation; 1 × 60: vaccine + two additional injections of CpG ODNs applied once 60 days before tumor inoculation; 2 × 60: vaccine + two additional injections of CpG ODNs applied twice 60 and 45 days before tumor inoculation; 3 × 60: vaccine + two additional injections of CpG ODNs applied three times 60, 45 and 30 days before tumor inoculation; 1 × 30: vaccine + two additional injections of CpG ODNs applied once 30 days before tumor inoculation; 2 × 30: vaccine + two additional injections of CpG ODNs applied twice 30 and 15 days before tumor inoculation; 3 × 30: vaccine + two additional injections of CpG ODNs applied three times 30, 15 and 7 days before tumor inoculation. The experiment was repeated three times.

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