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Table 4 The cytotoxicity of MNCs from peritoneal tissue was significantly enhanced after repeated vaccinations.

From: Tumor vaccine composed of C-class CpG oligodeoxynucleotides and irradiated tumor cells induces long-term antitumor immunity

Group

2 × 90d*

3 × 90d*

2 × 60d**

3 × 60d**

2 × 30d***

3 × 30d***

p-value a

0.024

0.004

0.056

0.004

0.006

<0.001

  1. a p-value: group compared to group vaccinated once 90, 60 or 30 days before tumor challenge
  2. * vaccination started 90 days before the injection of viable tumor cells; the vaccine was applied once (1×), twice (2×) or three times (3×) in 15 days interval
  3. ** vaccination started 60 days before the injection of viable tumor cells; the vaccine was applied once (1×), twice (2×) or three times (3×) in 15 days interval
  4. *** vaccination started 30 days before the injection of viable tumor cells; the vaccine was applied once (1×), twice (2×) or three times (3×) in 15 days interval, except for the last - third vaccination, which was performed 7 days after second vaccination
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BMC Immunology

ISSN: 1471-2172

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