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Figure 2 | BMC Immunology

Figure 2

From: Phenotype, functions and fate of adoptively transferred tumor draining lymphocytes activated ex vivo in mice with an aggressive weakly immunogenic mammary carcinoma

Figure 2

Therapeutic effect of AIT is mediated predominantly by CD8+T cells. Mice with established 4T1 flank tumors were either untreated, treated with CYP alone (on day 3) or CYP on day 3 + AIT on day 4 with 20 × 106 cells from culture. The cells infused for AIT were either untreated, treated with C' alone, treated with anti-CD8 Ab + C' or with anti-CD4 antibody + C' prior to transfer. Mean tumor sizes ± SE are charted over time. Numbers to the right indicate the number of mice with complete tumor regression per total number of mice in each group. The results with AIT using untreated, C' treated, and CD4-depleted cells were significantly different from the untreated group, the CYP only group, and the CD8-depleted AIT groups [F(4,24) = 32.45, P < 0.0001].

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