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Figure 6 | BMC Immunology

Figure 6

From: CD8+ T cell activation predominate early immune responses to hypercholesterolemia in Apoe-/- mice

Figure 6

Expression of IFN-γ and IL-10 in CD4+ and CD8+ cells in mediastinal lymph nodes (MeLN). Fig. A-C depicts MeLN cells at 4 weeks and fig. D-F depicts MeLN cells at 8 weeks. There was no difference in IL-10 or IFN-γ production in (A) CD4+ or (B) CD8+ cells between mice fed a high fat diet (HFD) and a chow diet. (C) HFD-fed mice expressed a higher fraction of IFN-γ producing CD8+CD28+ cells compared to mice fed chow diet. (D) Increased IFN-γ production of CD4+ cells of high fat diet (HFD) fed mice compared to CD4+ cells from mice fed a chow diet. (E) No difference in the relative size of CD8+IFN-γ+ and CD8+IL-10+ cells between mice fed HFD and chow diet. (F) Increased IFN-γ production in CD8+CD28+ cells in HFD-fed mice compared to mice fed chow diet. *P < 0.05, **P < 0.01.

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