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Figure 4 | BMC Immunology

Figure 4

From: Iloprost modulates the immune response in systemic sclerosis

Figure 4

Iloprost treatment increases TGF β production from PBMCs after stimulus with PHA. TGF β was measured in the culture supernatants of PBMCs from SSc patients treated with iloprost at baseline and after treatment (5 days of daily treatment, 28 days after the last infusion), cultures were stimulated or not with PHA which predominantly stimulates T cells. A. Graph shows the level of TGF β supernatants 24 hrs after stimulus with PHA (dotted line) or without (continuous line). Symbols represent mean and SD, for all the patients, p values were calculated with the Wilcoxon test, significant values are displayed. B. In vitro challenge of PBMCs culture with iloprost for 15 and 120 min, after 24 hrs of PHA or without further stimulus. Graph shows the TGF β in PBMCs, TGF β expression was corrected for expression of the housekeeping gene β actin. Bars represent mean and SD of five independent experiments.

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