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Figure 4 | BMC Immunology

Figure 4

From: Lack of the pattern recognition molecule mannose-binding lectin increases susceptibility to influenza A virus infection

Figure 4

White blood cells (WBC) and apoptosis susceptibility. A, Total WBC are expressed as cells per lung. B, PMN population as % of total WBC. C, Macrophage population as % of total WBC. For all experiments A - C, two experiments were combined. Mice numbers used were 5 wild type (WT) and 7 MBL null for day 1; 6 WT and 7 MBL null for day 4; and 8 WT and 7 MBL null for day 7. Data are expressed as mean ± SE. **, p < 0.005 and ***, p < 0.001. D, Increased apoptotic macrophages (%) in BAL cells of MBL null mice on day 1 post-IAV infection. Experiments were as in Figure 4A. Five wild type (WT) and 7 MBL null mice were used. Data are expressed as mean ± SE. **, p < 0.005. E, Viral infection induced cell death. Macrophages (MΦ) from WT and MBL null mice were incubated with virus and cell death was expressed as % of WT MΦ without viral infection. Assays were performed in triplicate. Data are expressed as mean ± SE. *, p < 0.05; **, p < 0.005; and ***, p < 0.0001.

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