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Table 3 Hsp70 and cytokine serum concentrations

From: Circulating Heat Shock Protein 70 in Health, Aging and Disease

Parameter Infl. Geriatric Patients N = 56 Non-infl. Geriatric Patients N = 34 Community-Dwelling Elderly N = 100 Young Adults N = 100
Hsp70 (ng/mL)     
Median [IQR]* 0.22 [0.19; 0.58] 0.19 [0.19; 0.21] 0.19 [0.19; 0.50] 0.40 [0.19; 0.67]‡$
Detectable/Undetectable* 29/27 9/25 47/53 72/28 $
IL-6 (pg/mL Standard)     
Median [IQR] a * 27.03 [16.38; 48.84] 12.78 [8.95; 16.88] 13.15 [9.99; 16.99] 9.29 [8.56; 11.97]†$
Detectable/Undetectable* 46/10 13/21 28/72 19/81
IL-6 (pg/mL Hs)     
Median [IQR] a * 3.95 [2.69; 6.82] 4.32 [2.49; 4.91] 2.09 [1.29; 3.27]†‡ 0.89 [0.70; 1.46]†‡$
Detectable/Undetectable* 10/0 21/0 71/1 63/18
TNF-alpha (pg/mL)     
Median [IQR]* 15.65 [11.87; 21.66] 12.93 [10.06; 17.99] 12.49 [10.81; 15.73] 12.07 [10.09; 13.87]†$
Detectable/Undetectable 56/0 34/0 100/0 100/0
IL-10 (pg/mL)     
Median [IQR]* 0.99 [0.99; 2.12] 0.99 [0.99; 0.99] 0.99 [0.99; 1.81] 1.97 [0.99; 2.97]†‡$
Detectable/Undetectable* 19/37 5/29 45/55 64/36†‡$
  1. IQR = interquartile range (percentile25; percentile 75); Infl = inflammatory (CRP serum concentration ≥5 mg/L); aValues based on samples with detectable concentrations only; Standard = standard IL-6 kit with a detection limit of 7.8 pg/mL; Hs = high-sensitivity IL-6 kit with a detection limit of 0.16 pg/mL.
  2. *Significant differences among groups (Kruskall-Wallis test or Chi-Square test p < 0.001); significantly different from Inflammatory geriatric patients, Non-inflammatory geriatric patients, $ Community-dwelling elderly (Mann-Whitney U test or Chi-Square test p < 0.05).