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Table 3 Hsp70 and cytokine serum concentrations

From: Circulating Heat Shock Protein 70 in Health, Aging and Disease

Parameter

Infl. Geriatric Patients

N = 56

Non-infl. Geriatric Patients

N = 34

Community-Dwelling Elderly

N = 100

Young Adults

N = 100

Hsp70 (ng/mL)

    

Median [IQR]*

0.22 [0.19; 0.58]

0.19 [0.19; 0.21]†

0.19 [0.19; 0.50]‡

0.40 [0.19; 0.67]‡$

Detectable/Undetectable*

29/27

9/25†

47/53‡

72/28 † ‡ $

IL-6 (pg/mL Standard)

    

Median [IQR] a *

27.03 [16.38; 48.84]

12.78 [8.95; 16.88]†

13.15 [9.99; 16.99]†

9.29 [8.56; 11.97]†$

Detectable/Undetectable*

46/10

13/21†

28/72†

19/81 † ‡

IL-6 (pg/mL Hs)

    

Median [IQR] a *

3.95 [2.69; 6.82]

4.32 [2.49; 4.91]

2.09 [1.29; 3.27]†‡

0.89 [0.70; 1.46]†‡$

Detectable/Undetectable*

10/0

21/0

71/1

63/18‡

TNF-alpha (pg/mL)

    

Median [IQR]*

15.65 [11.87; 21.66]

12.93 [10.06; 17.99]†

12.49 [10.81; 15.73]†

12.07 [10.09; 13.87]†$

Detectable/Undetectable

56/0

34/0

100/0

100/0

IL-10 (pg/mL)

    

Median [IQR]*

0.99 [0.99; 2.12]

0.99 [0.99; 0.99]†

0.99 [0.99; 1.81]‡

1.97 [0.99; 2.97]†‡$

Detectable/Undetectable*

19/37

5/29†

45/55‡

64/36†‡$

  1. IQR = interquartile range (percentile25; percentile 75); Infl = inflammatory (CRP serum concentration ≥5 mg/L); aValues based on samples with detectable concentrations only; Standard = standard IL-6 kit with a detection limit of 7.8 pg/mL; Hs = high-sensitivity IL-6 kit with a detection limit of 0.16 pg/mL.
  2. *Significant differences among groups (Kruskall-Wallis test or Chi-Square test p < 0.001); significantly different from †Inflammatory geriatric patients, ‡ Non-inflammatory geriatric patients, $ Community-dwelling elderly (Mann-Whitney U test or Chi-Square test p < 0.05).