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Table 4 Relationship between the inflammatory parameters and Hsp70 in patients and control subjects

From: Circulating Heat Shock Protein 70 in Health, Aging and Disease

  Age (years) CRP (mg/L) TNF-alpha (pg/mL) IL-6 (Rank order)a IL-10 (pg/mL)
Hsp70 (ng/mL)      
   Patients (n = 90) -0.106 0.379** 0.145 0.287** 0.045
   Controls (n = 200) -0.194** NA -0.035 -0.118 -0.041
IL-10 (pg/mL)      
   Patients (n = 90) -0.051 0.223* 0.327** 0.234*  
   Controls (n = 200) -0.185** NA 0.162* 0.073  
IL-6 (Rankorder) a      
   Patients (n = 90) 0.117 0.699** 0.354**   
   Controls (n = 200) 0.421** NA 0.332**   
TNF-alpha (pg/mL)      
   Patients (n = 90) 0.110 0.303**    
   Controls (n = 200) 0.149* NA    
CRP (mg/L)      
   Patients (n = 90) -0.029     
   Controls (n = 200) NA     
  1. NA = not applicable; aSerum samples with the concentration of IL-6 lower than 7.8 pg/mL, which was the lower detection limit for the standard IL-6 kit, were re-analysed using the high-sensitive IL-6 kit with a detection limit of 0.16 pg/mL. In order to bring results for IL-6 obtained by the standard and high-sensitivity assays together, a ranking method was applied whereby the values obtained with the high-sensitivity kit were ranked from low to high followed by the values obtained with the standard kit from low to high. Values represent Spearman's rho correlation coefficients, * p < 0.05, ** p < 0.001.