Circulating Heat Shock Protein 70 in Health, Aging and Disease

BMC Immunology

Table 4 Relationship between the inflammatory parameters and Hsp70 in patients and control subjects

	Age (years)	CRP (mg/L)	TNF-alpha (pg/mL)	IL-6 (Rank order)^a	IL-10 (pg/mL)
Hsp70 (ng/mL)
Patients (n = 90)	-0.106	0.379**	0.145	0.287**	0.045
Controls (n = 200)	-0.194**	NA	-0.035	-0.118	-0.041
IL-10 (pg/mL)
Patients (n = 90)	-0.051	0.223*	0.327**	0.234*
Controls (n = 200)	-0.185**	NA	0.162*	0.073
IL-6 (Rankorder) ^a
Patients (n = 90)	0.117	0.699**	0.354**
Controls (n = 200)	0.421**	NA	0.332**
TNF-alpha (pg/mL)
Patients (n = 90)	0.110	0.303**
Controls (n = 200)	0.149*	NA
CRP (mg/L)
Patients (n = 90)	-0.029
Controls (n = 200)	NA

NA = not applicable; ^aSerum samples with the concentration of IL-6 lower than 7.8 pg/mL, which was the lower detection limit for the standard IL-6 kit, were re-analysed using the high-sensitive IL-6 kit with a detection limit of 0.16 pg/mL. In order to bring results for IL-6 obtained by the standard and high-sensitivity assays together, a ranking method was applied whereby the values obtained with the high-sensitivity kit were ranked from low to high followed by the values obtained with the standard kit from low to high. Values represent Spearman's rho correlation coefficients, * p < 0.05, ** p < 0.001.

ISSN: 1471-2172