Skip to main content
Figure 2 | BMC Immunology

Figure 2

From: Role of epithelial integrin-linked kinase in promoting intestinal inflammation: effects on CCL2, fibronectin and the T cell repertoire

Figure 2

Epithelial ILK provides a pro-inflammatory stimulus in acute colitis. A. Acute colitis was induced in mice using 3.5% DSS in the drinking water. Mice were weighed daily, and the results after 7 days of DSS treatment, and following a further 8 days off DSS are shown. The weights expressed as the percentage of original (mean ± SEM) are shown (1 = WT control, 2 = WT+DSS, 3 = ILK-ko (C), 4 = ILK-ko + DSS). There is a significant attenuation of the normally observed weight loss in the ILK-ko mice at day 7 (p < 0.05, ANOVA, Tukey post-test). B. Representative histological slides for each of the DSS treated groups are shown. The inflammatory infiltrate, surface epithelial disruption and edema are reduced in the ILK-ko animals. There was a significant reduction in the inflammatory scores in the ILK-ko mice (n = 6 per group).

Back to article page