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Figure 1 | BMC Immunology

Figure 1

From: Prevalent de novo somatic mutations in superantigen genes of mouse mammary tumor viruses in the genome of C57BL/6J mice and its potential implication in the immune system

Figure 1

MMTV SAg isoforms isolated from the genomic DNA of various tissues of normal C57BL/6J mice. A. Phylogenetic tree (nucleotide sequence) of MMTV SAg isoforms. The three sets of unique MMTV SAg isoforms, which were isolated from the liver, lungs, and bone marrow, were phylogenetically analyzed. A number of unique branching units of SAg isoforms were formed in the phylogenetic tree. Unique SAg isoforms that were found in more than one tissue type are indicated using various shapes and shades. Four reference SAg sequences from Mtv-8, Mtv-9, Mtv-17, and Mtv-30 were included for this analysis. B. Phylogenetic tree (putative amino acid sequence) of SAg isoforms. The three sets (liver, lungs, and bone marrow) of unique SAg isoforms were analyzed and a phylogenetic tree with a number of unique branching units of SAg isoforms was formed. Unique SAg isoforms that were found in more than one tissue type are indicated using various shapes and shades. Four reference SAg sequences from Mtv-8, Mtv-9, Mtv-17, and Mtv-30 were included for this analysis. The translated sequence of gLi-N18 was not included in the analysis due to its short length resulting from a premature stop codon. black circle (identical to Mtv-8); black triangle (identical to Mtv-17); gray circle (identical to Mtv-9); gray triangle, gray box, and black box (identical sequences among different tissue types). gLi (liver genomic DNA), gLu (lung genomic DNA), gBM (bone marrow genomic DNA), N (normal tissue)

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