Effects of CP690, 550 activated CD4+ T cell cytokine production. CD4+ T cells were stimulated with CD3 monoclonal antibodies in the presence or absence of CP690,550 for 48 hr. Supernatants were collected and the levels of IL-2, IL-4 (A), IFN-γ (B), IL-17A (C), IL-22 (D) and IL-2 (E) were measured by ELISA. The figure shows the means ± SD of the three independent experiments performed in triplicate. * p < 0.001 vs CD3 Ab-stimulated lymphocytes.