Figure 8

The impact of PD-1 stimulation on the biology of PD-1-expressing T cells. The PD-1-expressing T cells were cultured in various conditions in the presence or absence of PD-L2-Fc protein. CXCL13 production (A), cell proliferation (B), and B cell-helping activities (C) were determined. The data in panels A and B were from T cell only cultures. The cells were activated with antibodies to CD3 and CD28 in the presence of IL-2. Combined data of 3 independent experiments are shown. "*"indicates significant differences.