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Table 2 Hemodynamic and microvascular parameters in cremaster muscle venules during TNF-α-induced inflammation

From: RAGE and ICAM-1 differentially control leukocyte recruitment during acute inflammation in a stimulus-dependent manner

 

Mice

Venules

Diameter

Centerline

Velocity

Wall shear

rate

Systemic

leukocyte counts

 

(N)

(n)

(μm)

(μm/s)

(s-1)

(cells/μl)

Wild type

6

6

30 ± 3

2200 ± 200

1800 ± 100

6300 ± 1000

RAGE -/-

5

5

32 ± 2

2800 ± 200

2200 ± 200

4200 ± 700

Icam1 -/-

4

4

30 ± 2

2400 ± 300

2000 ± 300

6400 ± 300

Wild type +

anti-Mac-1

4

20

29 ± 2

2200 ± 100

2000 ± 100

4200 ± 200

Icam1-/- +

anti-Mac-1

3

13

30 ± 2

2500 ± 100

2000 ± 100

4800 ± 400

Wild type + isotype

3

10

30 ± 2

2500 ± 100

2100 ± 100

4000 ± 500

Wild type +

anti-LFA-1

4

13

28 ± 2

2400 ± 100

2100 ± 100

4900 ± 300

Icam1-/- +

anti-LFA-1

3

14

27 ± 3

2200 ± 200

2400 ± 400

5000 ± 300

Wild type + isotype

3

9

31 ± 2

2500 ± 100

2100 ± 200

4600 ± 300

   

n.s.

n.s.

n.s.

n.s.

  1. Vessel diameter, centerline velocity, wall shear rate and systemic leukocyte counts are presented as mean ± SEM of the investigated venules during TNF-α-induced inflammation with additional local fMLP superfusion and after anti-Mac-1 and anti-LFA-1 antibody treatment. n.s. = non significant.