CD3+ T cells migrate into the lung in absence of STAT6. Allergic lung disease was induced in RAG2-/-, STAT6xRAG2-/- or IL-4RαxRAG2-/- mice as described above. Images (10×, 40× and 100× magnifications) of representative lung sections stained with antibodies to CD3 are shown in (A). CD3+ cells appear brown. Panels a-c: RAG2-/- lung sections; d-f: STAT6xRAG2-/- sections and g-i: IL-4RαxRAG2-/- sections. n = 5 for each mouse strain. (B) Graphical representation of the immunohistochemistry data shown above. Number of CD3+ cells in each lung section was counted and graphed. Data represented as cell counts ± SEM. HPF: high power field; 100×. * p < 0.05.