Figure 3

Leukocyte repulsion by ketoprofen: Representative images (A) and quantitative analysis (B) of leukocyte penetration of collagen matrix in vitro. C: Prevention of leukocyte infiltration after topic application of ketoprofen in vivo prior the IL-8 injection. D: Representative image of intravital microscopy. Leukocytes appeared in green, blood vessels were visualized using i.v. injection of TRITC-conjugated albumin (orange). IL-8 strongly activated leukocyte extravasation and migration, whereas almost no leukocytes were found if ketoprofen gel was locally applied on skin prior the IL-8 injection.