TY - JOUR AU - Szema, Anthony M. AU - Hamidi, Sayyed A. AU - Koller, Antonius AU - Martin, Dwight W. PY - 2011 DA - 2011/11/21 TI - Vasoactive Intestinal Peptide Knockout (VIP KO) mouse model of sulfite-sensitive asthma: up-regulation of novel lung carbonyl reductase JO - BMC Immunology SP - 66 VL - 12 IS - 1 AB - We earlier reported spontaneous features of asthma in Vasoactive Intestinal Peptide knockout mice (VIP KO): 1) peribronchiolar airway inflammation, with accumulation of lymphocytes and eosinophils, 2) pro-inflammatory cytokine production of IL-5, IL-6, with IFN-γ, and 3) airway hyper-responsiveness to inhaled methacholine. In human asthma, a phenotype with sulfite sensitivity leads to airway inflammation and hyper-responsiveness to inhaled sulfites, and is associated with upregulation of anti-oxidant protein lung carbonyl reductase. For the present experiments, we examined the role of VIP in modulating anti-oxidant genes and their proteins, including lung carbonyl reductase. SN - 1471-2172 UR - https://doi.org/10.1186/1471-2172-12-66 DO - 10.1186/1471-2172-12-66 ID - Szema2011 ER -