Skip to main content
Figure 2 | BMC Immunology

Figure 2

From: Indispensable roles of OX40L-derived signal and epistatic genetic effect in immune-mediated pathogenesis of spontaneous pulmonary hypertension

Figure 2

Clinicopathological phenotypes associated with PH. (A) Significant elevation of RVSP (mmHg) in B6.TgL. The result represents a mean ± standard deviation (SD) of 4 B6 or 6 B6.TgL mice (20 to 24 weeks old) for each group. (B) Correlation between RVSP values and PAH scores obtained from the 10 mice examined in A. The significance of this correlation was confirmed with the Kendall tau (τ) rank correlation coefficient (τ = 0.828). (C) RV hypertrophy manifested in B6.TgL. RV hypertrophy was evaluated with the index provided by the formula, RV/(LV+IVS). The result represents a mean ± SD of 12 B6 or 8 B6.TgL mice for each group. The significant difference between the two groups was evaluated by two-tailed t-test. *, p < 0.05; **, p < 0.01.

Back to article page