Figure 5

Antibody production of FOB or MZB cells from B6 or B6.TC mice. Total IgM (A-F), anti-ssDNA (G-H) and dsDNA IgM (I) production in supernatants from 5 d cultures with LPS (A, G, I), CpG (B), protein ICs (C), chromatin ICs (D), anti-CD40 (E, H), and B6 or B6.TC CD4⁺ T cells (F). Results are expressed as fold increase over the IgM production by the corresponding B cell type and strain in the absence of any stimulation. Results are representative of two independent assays with 3 mice per strain in each. Means and SEM, Student t test comparisons: *: p < 0.05; **: p < 0.01, ***: p < 0.001.