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Figure 3 | BMC Immunology

Figure 3

From: Neuroantigen-specific, tolerogenic vaccines: GM-CSF is a fusion partner that facilitates tolerance rather than immunity to dominant self-epitopes of myelin in murine models of experimental autoimmune encephalomyelitis (EAE)

Figure 3

The murine GMCSF-MOG TTV induced tolerance and prevented a subsequent episode of EAE. C57BL/6 mice were treated with 2 nmoles of GMCSF-MOG, 2 nmoles of MOG35-55, or saline on days -21, -14, and -7 before active challenge on day 0 with 200 ug of MOG35-55 in CFA and two i.p. injections of Pertussis toxin on days 0 and 2. Table 1 and Figure 3 portray the same experiment. In experiment #1 (A-B), daily clinical disease scores for mice treated with GMCSF-MOG were significantly different from those treated with MOG35-55 (days 16-34). Comparison of "GMCSF-MOG versus saline" groups also revealed significant differences from days 15-19 and 24-28. In experiment #2 (C-D), daily clinical scores for GMCSF-MOG treated mice were significantly different from mice treated with MOG35-55 (days 13-30) or saline (days 11-30).

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BMC Immunology

ISSN: 1471-2172

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