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Figure 6 | BMC Immunology

Figure 6

From: Neuroantigen-specific, tolerogenic vaccines: GM-CSF is a fusion partner that facilitates tolerance rather than immunity to dominant self-epitopes of myelin in murine models of experimental autoimmune encephalomyelitis (EAE)

Figure 6

The murine GMCSF-PLP TTV induced tolerance and prevented a subsequent episode of EAE. SJL mice were treated with 2 nmoles of GMCSF-PLP (n = 8 each group), 2 nmoles of PLP139-151, or saline on days -21, -14, and -7 before active challenge on day 0 (200 ug of PLP139-151 in CFA). Table 3 and Figure 6 represent the same experiment. Daily clinical scores for mice treated with GMCSF-PLP(139-151) were significantly different from those treated with saline (days 12-15, 18-22, 25-34).

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