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Figure 7 | BMC Immunology

Figure 7

From: Neuroantigen-specific, tolerogenic vaccines: GM-CSF is a fusion partner that facilitates tolerance rather than immunity to dominant self-epitopes of myelin in murine models of experimental autoimmune encephalomyelitis (EAE)

Figure 7

The murine GMCSF-PLP and GMCSF-MOG TTV targeted NAg to APC for enhanced antigen presentation. A PLP139-151-specific T cell line (A-B) or MOG35-55-specific T cell line (C-D) was cultured with irradiated SJL splenocytes (A), irradiated SJL thymocytes (B), or irradiated C57BL/6 splenocytes (C-D) as a source of APC together with designated concentrations (x-axis) of GMCSF-NAg, antigen, GM-CSF, or PLP139-151. C and D show the same data plotted on linear and logarithmic y-axes. Cultures were pulsed with [3H]thymidine during the last 24 hrs of a 72 hr culture. These data are representative of three experiments.

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BMC Immunology

ISSN: 1471-2172

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