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Figure 8 | BMC Immunology

Figure 8

From: Neuroantigen-specific, tolerogenic vaccines: GM-CSF is a fusion partner that facilitates tolerance rather than immunity to dominant self-epitopes of myelin in murine models of experimental autoimmune encephalomyelitis (EAE)

Figure 8

GMCSF-MOG was an effective intervention that prevented progression of EAE. Mice were immunized on day 0 with 200 ug MOG35-55 in CFA plus Pertussis toxin (200 ng i.p.) on days 0 and 2. Treatment was initiated when the first mice began showing clinical signs. Mice were matched for clinical signs and were injected subcutaneously with saline or 2 nanomoles of the synthetic peptide MOG35-55 or 2 nanomoles of the GMCSF-MOG TTV (in saline) on days 13, 15, 17, and 20. Table 4 and Figure 8 represent the same experiment. Daily clinical scores for mice treated with GMCSF-MOG significantly differed from those treated with MOG35-55 (days 16-38) or saline (days 15-38). Daily clinical scores for mice treated with MOG35-55 were significantly different from those treated with saline (days 18-22, 24, 32-36).

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BMC Immunology

ISSN: 1471-2172

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