The effect of caries on the transcription of genes highly expressed in normal teeth. Expression of IL1R1 (A), MIF (B), CXCL12 (C), and CXCL14 (D) in ODL and pulp of normal versus carious teeth was determined by real-time PCR. Values are reported as relative fold change in mRNA transcription of normal versus carious samples. The data represent means and standard errors from triplicate wells of one experiment and are representative of three independent experiments. Asterisks indicate statistically significant changes, with P < 0.05.