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Figure 4 | BMC Immunology

Figure 4

From: Increased levels of prolactin receptor expression correlate with the early onset of lupus symptoms and increased numbers of transitional-1 B cells after prolactin treatment

Figure 4

SLE manifestations in mice with hyperprolactinaemia. Fourteen C57BL/6 and MRL/lpr mice, and seven MRL mice at 9 weeks of age were treated for 6 weeks with metoclopramide (100 μg/100 μl) or PBS (100 μl). At the end of the treatment, the following measurements were taken: A) PRL concentration by ELISA; B) level of proteinuria using reactive strips; C) anti-dsDNA IgG antibodies; and D) anti-dsDNA antibodies of the IgG1 and IgG2a isotypes in the MRL and MLR/lpr mice by ELISA. The asterisks denote statistical significance between groups with the p value shown. HyperPRL = Hyperprolactinaemic

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BMC Immunology

ISSN: 1471-2172

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