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Figure 2 | BMC Immunology

Figure 2

From: Molecular pathway profiling of T lymphocyte signal transduction pathways; Th1 and Th2 genomic fingerprints are defined by TCR and CD28-mediated signaling

Figure 2

PMA/CD3 and CD3/28 stimulations differ from PMA/CD28 stimulation. The table shows the number of regulated probe sets and their overlap at 1 and 8 hrs following stimulation with CD3/PMA, PMA/CD28 and CD3/CD28 (using a fold change cut off of 2 and a p-value cut off of < 1.10-6). The right panel shows a hierarchical clustering of the data using the data for the regulated probe sets. Most of the variation is caused by the time difference (1 hr vs 8 hrs). At both time points the PMA/CD28 stimulus was clearly different from the CD3/CD28 and CD3/PMA stimulus. Repeating this analysis with different values for the fold change and p-value cut off yielded essentially the same results for the multivariate analysis.

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BMC Immunology

ISSN: 1471-2172

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