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Figure 3 | BMC Immunology

Figure 3

From: Molecular pathway profiling of T lymphocyte signal transduction pathways; Th1 and Th2 genomic fingerprints are defined by TCR and CD28-mediated signaling

Figure 3

Differential regulation of IL-2 and CCL1. Jurkat T cells were activated for 1 and 8 hours using different stimuli (as indicated). Differentially regulated genes of which the proteins were secreted were identified and the highest ranking genes were selected. A; regulation of the CCL1 mRNA is highly and differentially regulated after PMA/CD28 stimulation. Right panel shows the validation of the mRNA levels on protein level, secreted by activated Jurkat T cells. B; regulation of IL-2 mRNA is highly and differentially regulated after CD3/28 and PMA/CD3 stimulation. Right panel shows the validation of the mRNA levels on protein, secreted by activated Jurkat T cells.

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